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KMID : 1240020150190010034
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International Neurourology Journal
2015 Volume.19 No. 1 p.34 ~ p.38
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Loss of Caveolin 1 is Associated With the Expression of Aquaporin 1 and Bladder Dysfunction in Mice
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:Jung Se-heon
:Kim Sun-Ouck/:Song Seung-Hee/:Kang Teak-Won/:Park Kwang-Sung/:Kwon Dong-Deuk/:Cho Kyung-Aa
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Abstract
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Purpose : It is suggested that caveolin and aquaporin might be closely associated with bladder signal activity. We investigated the effect of the deletion of caveolin 1, using caveolin 1 knockout mice, on the expression of aquaporin 1 in order to identify their relation in the urothelium of the urinary bladder.
Methods : The cellular localization and expressions of aquaporin 1 and caveolin 1, in the wild type and caveolin 1 knockout mice urinary bladder, were examined by Western blot and immunofluorescence techniques.
Results : Aquaporin 1 and caveolin 1 were coexpressed in the arterioles, venules, and capillaries of the suburothelial layer in the wild type controls. Aquaporin 1 protein expression was significantly higher in the caveolin 1 knockout mice than in the wild type controls (P <0.05).
Conclusions : The results imply that aquaporin 1 and caveolin 1 may share a distinct relation with the bladder signal activity. This might play a specific role in bladder dysfunction.
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KEYWORD
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Aquaporin 1, Caveolin 1, Bladder
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